Short Communication: Neutralizing Antibodies in HIV-1-Infected Brazilian Individuals
نویسندگان
چکیده
منابع مشابه
Elimination of HIV-1-infected cells by broadly neutralizing antibodies.
The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural killer (NK) engagement. These antibodies target the CD4-binding site, the glycans...
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A37 HIV drug resistance monitoring in children receiving first line antiretroviral therapy at two pediatric hospitals in Ho Chi Minh City Anh Q. Luong, Ton Tran, Khanh Thu H. Hoang, Ngoc Thao T. Do, Thinh X. Vu, Khanh H. Truong, Quy T. Du, Kim Thoa P. Le, Viet C. Do, An T. Vu, Thanh Thuy T. Le, Kim Chi T. Nguyen, Binh K. Nguyen, Hien. T Bui, Xuan Lien T. Truong, Pasteur Institute, Ho Chi Minh C...
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Previously we have discovered a public idiotope, designated 1F7, that is expressed on antibodies against HIV type 1 (HIV-1) in human and nonhuman primates. To test the potential of mouse monoclonal antibody (mAb) 1F7 as a therapeutic anti-clonotypic antibody in HIV-1-infected patients, we used the simian HIV-IIIB macaque infection model, which mimics several immunological and pathological chara...
متن کاملBroad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals
Broadly Cross clade Neutralizing (BCN) antibodies are recognized as potential therapeutic tools and leads for the design of a vaccine that can protect human beings against various clades of Human Immunodeficiency Virus (HIV). In the present study, we screened plasma of 88 HIV-1 infected ART naïve individuals for their neutralization potential using a standard panel of 18 pseudoviruses belonging...
متن کاملImmunologic characteristics of HIV‐infected individuals who make broadly neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) capable of inhibiting infection with diverse variants of human immunodeficiency virus type 1 (HIV-1) is a key, as-yet-unachieved goal of prophylactic HIV-1 vaccine strategies. However, some HIV-infected individuals develop bnAbs after approximately 2-4 years of infection, enabling analysis of features of these antibodies and the immunological...
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ژورنال
عنوان ژورنال: AIDS Research and Human Retroviruses
سال: 2013
ISSN: 0889-2229,1931-8405
DOI: 10.1089/aid.2012.0052